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Cyclosporin and neuronal apoptosis

1. Camandola S, Poli G, Mattson MP. The lipid peroxidation product 4-hydroxy-2,3-nonenal increases AP-1-binding activity through caspase activation in neurons. J Neurochem 2000;74(1):159-68.

2. Kingham PJ, Pocock JM. Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release. J Neurochem 2000;74(4):1452-62.

3. Kobayashi T. The roles of mitochondrial permeability transition in brain ischemia. Hokkaido Igaku Zasshi 2000;75(4):243-52. (in Japanese)

4. Mather M, Rottenberg H. Aging enhances the activation of the permeability transition pore in mitochondria. Biochem Biophys Res Commun 2000;273(2):603-8.

5. Petersen A, Castilho RF, Hansson O, Wieloch T, Brundin P. Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons. Brain Res. 2000;857(1-2):20-9.

6. Asai A, Qiu J, Narita Y, Chi S, Saito N, Shinoura N, et al. High level calcineurin activity predisposes neuronal cells to apoptosis. J Biol Chem 1999;274(48):34450-8.

7. Cassarino DS, Parks JK, Parker WD, Bennett JP. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta 1999;1453(1):49-62.

8. Chalmers-Redman RM, Fraser AD, Carlile GW, Pong A, Tatton WG. Glucose protection from MPP+-induced apoptosis depends on mitochondrial membrane potential and ATP synthase. Biochem. Biophys. Res. Commun. 1999;257(2):440-7.

9. Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM, Tatton WG. Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence. Biochem Biophys Res Commun 1999;261(1):123-30.

10. Cassarino DS, Parks JK, Parker WD, Jr., Bennett JP, Jr. The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta 1999;1453(1):49-62.

11. Chalmers-Redman RM, Fraser AD, Carlile GW, Pong A, Tatton WG. Glucose protection from MPP+-induced apoptosis depends on mitochondrial membrane potential and ATP synthase. Biochem Biophys Res Commun 1999;257(2):440-7.

12. Ferrand-Drake M, Friberg H, Wieloch T. Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia. Neuroscience 1999;90(4):1325-38.

13. Kruman, II, Mattson MP. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J Neurochem 1999;72(2):529-40.

14. Ryu BR, Choi DW, Hartley DM, Costa E, Jou I, Gwag BJ. Attenuation of cortical neuronal apoptosis by gangliosides. J Pharmacol Exp Ther 1999;290(2):811-6.

15. Cassarino DS, Swerdlow RH, Parks JK, Parker WD, Jr., Bennett JP, Jr. Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem Biophys Res Commun 1998;248(1):168-73.

16. Dubinsky JM, Levi Y. Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons. J Neurosci Res 1998;53(6):728-41.

17. Fall CP, Bennett JP, Jr. MPP+ induced SH-SY5Y apoptosis is potentiated by cyclosporin A and inhibited by aristolochic acid. Brain Res 1998;811(1-2):143-6.

18. Friberg H, Ferrand-Drake M, Bengtsson F, Halestrap AP, Wieloch T. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. J Neurosci 1998;18(14):5151-9.

19. Holtsberg FW, Steiner MR, Bruce-Keller AJ, et al. Lysophosphatidic acid and apoptosis of nerve growth factor- differentiated PC12 cells. J Neurosci Res 1998;53(6):685-96.

20. Holtsberg FW, Steiner MR, Keller JN, Mark RJ, Mattson MP, Steiner SM. Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons. J Neurochem 1998;70(1):66-76.

21. Huser J, Rechenmacher CE, Blatter LA. Imaging the permeability pore transition in single mitochondria. Biophys J 1998;74(4):2129-37.

22. Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J Neurosci 1998;18(12):4439-50.

23. Keller JN, Kindy MS, Holtsberg FW, et al. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 1998;18(2):687-97.

24. Kruman, II, Nath A, Mattson MP. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol 1998;154(2):276-88.

25. Marzo I, Brenner C, Zamzami N, et al. The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med 1998;187(8):1261-71.

26. Seaton TA, Cooper JM, Schapira AH. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Brain Res 1998;809(1):12-7.

27. Tatton WG, Chalmers-Redman RM. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Ann Neurol 1998;44(3 Suppl 1):S134-41.

28. Wood AM, Bristow DR. N-methyl-D-aspartate receptor desensitisation is neuroprotective by inhibiting glutamate-induced apoptotic-like death. J Neurochem 1998;70(2):677-87.

29. Hortelano S, Dallaporta B, Zamzami N, et al. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition. FEBS Lett 1997;410(2-3):373-7.

30. Ankarcrona M, Dypbukt JM, Orrenius S, Nicotera P. Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett 1996;394(3):321-4.

31. Siesjo BK, Siesjo P. Mechanisms of secondary brain injury. Eur J Anaesthesiol 1996;13(3):247-68.



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