Latest Research


Alzheimer´s disease

1. Bachurin SO, Shevtsova EP, Kireeva EG, Oxenkrug GF, Sablin SO.
Mitochondria as a target for neurotoxins and neuroprotective agents.
Ann N Y Acad Sci. 2003 May;993:334-44; discussion 345-9.

2. Kim HS, Lee JH, Lee JP, Kim EM, Chang KA, Park CH, Jeong SJ, Wittendorp MC, Seo JH, Choi SH, Suh YH. Amyloid beta peptide induces cytochrome C release from isolated mitochondria. Neuroreport.
2002 Oct 28;13(15):1989-93.

3. Sola S, Diogenes MJ, Brites D, Rodrigues CM. [Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria]. Acta Med Port.
2002 Jul-Aug;15(4):269-75.

4. Chen QS, Wei WZ, Shimahara T, Xie CW. Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus.
Neurobiol Learn Mem. 2002 May;77(3):354-71.

5. Ghribi O, DeWitt DA, Forbes MS, Arad A, Herman MM, Savory J.
Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits. J Alzheimers Dis. 2001 Aug;3(4):387-391.

6. Parks JK, Smith TS, Trimmer PA, Bennett JP Jr, Parker WD Jr.
Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro.
J Neurochem. 2001 Feb;76(4):1050-6.

7. Rodrigues CM, Sola S, Silva R, Brites D. Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization. Mol Med. 2000 Nov;6(11):936-46.

8. Brera B, Serrano A, de Ceballos ML. Beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress. Neurobiol Dis.
2000 Aug;7(4):395-405.

9. Lee RK, Wurtman RJ. Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors.
Ann N Y Acad Sci. 2000;920:261-8.

10. Ham D, Schipper HM. Heme oxygenase-1 induction and mitochondrial iron sequestration in astroglia exposed to amyloid peptides. Cell Mol Biol (Noisy-Le-Grand) 2000;46(3):587-96.

11. Kingham PJ, Pocock JM. Microglial apoptosis induced by chromogranin A is mediated by mitochondrial depolarisation and the permeability transition but not by cytochrome c release. J Neurochem 2000;74(4):1452-62.

12. Borlongan CV, Stahl CE, Keep MF, Elmer E, and Watanabe S. Cyclosporine-A enhances choline acetyltransferase immunoreactivity in the septal region of adult rats. Neuroscience Letters, 279: 73-76, 2000.

13. Lee RK, Knapp S, Wurtman RJ. Prostaglandin E2 stimulates amyloid precursor protein gene expression: inhibition by immunosuppressants.
J Neurosci. 1999 Feb 1;19(3):940-7.

14. Cassarino DS, Swerdlow RH, Parks JK, Parker WD, Jr., Bennett JP, Jr. Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem Biophys Res Commun 1998;248(1):168-73.

15. Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J Neurosci 1998;18(12):4439-50.

16. Snyder SH, Sabatini DM, Lai MM, Steiner JP, Hamilton GS, Suzdak PD. Neural actions of immunophilin ligands. Trends Pharmacol Sci 1998;19(1):21-6.

17. Tatton WG, Chalmers-Redman RM. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Ann Neurol 1998;44(3 Suppl 1):S134-41.

18. Borlongan CV, Fujisaki T, Watanabe S. Chronic administration of cyclosporine A does not impair memory retention in rats. Neuroreport 1997;8(3):673-6.

19. Sabatini DM, Lai MM, Snyder SH. Neural roles of immunophilins and their ligands. Mol Neurobiol 1997;15(2):223-39.

20. Kondo Y, Ogawa N, Asanuma M, Nishibayashi S, Iwata E, Mori A. Cyclosporin A prevents ischemia-induced reduction of muscarinic acetylcholine receptors with suppression of microglial activation in gerbil hippocampus. Neurosci Res 1995;22(1):123-7.

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